e American Physiological Society (APS) is a nonprofit devoted to fostering education, scientific research, and dissemination of information in the physiological sciences. The Society was founded in 1887 with 28 members. APS now has over 10,500 members. Most members have doctoral degrees in physiology and/or medicine (or other health professions).

APS is governed by an elected Council consisting of a President, President-Elect, Past President, and nine Councillors. The National headquarters of the Society is based in Rockville, Maryland.

APS is a member of the Federation of American Societies for Experimental Biology (FASEB), a coalition of 26 independent societies that plays an active role in lobbying for the interests of biomedical scientists.